RESEARCH AREAS & PUBLICATIONS

The department of pharmacology is expertise in research areas such as Nanoparticle toxicology, Diabetes, Pharmacokinetics, Drug Interaction, Cancer, Herbal Medicine, Immunomodulation, etc. The department has made of significant contribution to the research field in terms of research publication and collaborative project works.

PATENTS/BOOKS/PUBLICATIONS

PATENTS

  • 1. Ramesh Banglore, Bharanil Srikonda, Rama Krishna Devarakonda, Mogili Ravula, Srihari Somu, Rama Narsimha Reddy Anreddy, Ravinder Manchal. Metal complexes with anticancer activity. US Patent No: US2010/0209537 A1 dated 19-08-2010
  • PUBLICATIONS

    • 1. G. Kiranmai and A. Rama Narsimha Reddy. Antioxidative status in rats following exposure of MgO nanoparticles. Toxicology and Industrial Health (Online first; Accepted; Impact factor=1.423)
    • 2. Shyam Sunder A, Sreekanth T, Raja Narender B, Rajeshwar Y, Rama Narsimha Reddy A, Satyavati D. Antimicrobial and Antimalarial Activity of Novel Synthetic Mononuclear Ruthenium(II) Compounds. Journal of the Chinese Chemical Society. 2013; 60(2):153-159 (Impact factor=0.68)
    • 3. G. Rajyalakshmi, A. Rama Narsimha Reddy, G. Kiran, Y. Narsimha Reddy and M. Sarangapani. Synthesis, antimicrobial, antioxidant and anticancer activities of some novel 3-(benzoxazol-2-ylimino) indolin-2-one derivatives. Journal of Chilean Chemical Society. (Accepted; Impact Factor=0.7)
    • 4. P. Maheshwari, B. Baburao and A. Rama Narsimha Reddy. Hepatoprotective activity of methanolic extract of Hiptage bengalensis leaves against CCl4 induced hepatotoxicity in rats. Toxicology Mechanisms and Methods, 2012;22(6):483-7 ( Impact factor=1.033)
    • 5. A. Rama Narsimha Reddy, Y. Narsimha Reddy, Devarakonda R. Krishna and V. Himabindu. Pulmonary Toxicity Assessment of Multi-wall Carbon Nanotubes in Rats following Intratracheal Instillation. Environmental Toxicology, 2012; 27(4):211-219 (Impact factor=2.407)
    • 6. E. Rajanarendar, S. Raju, M. Nagi Reddy, S. Rama Krishna, L. Hari Kiran, A. Rama Narsimha Reddy, Y. Narsimha Reddy. Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides. European Journal of Medicinal Chemistry 2012; 50: 274-279 ( Impact factor=3.4)
    • 7. G. Rajyalakshmi, A. Rama Narsimha Reddy and M. Sarangapani. Synthesis and biological activities of some novel 2-amino-(5 or 7-substituted-2-oxoindolin-3-ylidene) benzoxazole-5-carbohydrazide derivatives. Letters in Drug Design and Discovery 2012; 9(6):625-632 ( Impact factor=0. 872)
    • 8. E. Rajanarendar, M. Nagi Reddy, K. Rama Murthy, P. Surendar, A.R.N.Reddy, Y. N. Reddy. Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepines. Bioorganic & Medicinal Chemistry Letters, 2012; 22(1):149-153 (Impact factor=2.661)
    • 9. Rajyalakshmi G, Rama Narsimha Reddy A, Narsimha Reddy Y and Sarangapani M. Synthesis, characterization and anti-cancer activity of some novel 3-(4-[5-mercapto-1, 3, 4-oxadiazole-2-yl] phenylimino) – substituted – indolin – 2 – one derivatives. Saudi Pharmaceutical Journal. 2011; 19:153-158 (Impact factor=0.662)
    • 10. A. Rama Narsimha Reddy, M. Venkateswer Rao, D. R. Krishna, V. Himabindu and Y. Narsimha Reddy. Evaluation of oxidative stress and antioxidant status in rats following exposure of Carbon Nanotubes. Regulatory Toxicology and Pharmacology , 2011; 59:251-257 (Impact factor=2.427)
    • 11. Rajyalakshmi G, Rama Narsimha Reddy A, and Sarangapani M. Synthesis, characterization, anti-cancer and antioxidant activities of some novel N-(benzo[d]oxazol-2-yl) -2-(7 or 5-substituted-2-oxoindolin-3-ylidene) hydrazine - carboxamide derivatives. J Enzyme Inhibition & Medicinal Chemistry, 2011; 26(6):813-818 (Impact factor=1.617)
    • 12. Anreddy Rama Narsimha Reddy, Yellu Narsimha Reddy, Devarakonda Rama Krishna and Vurimindi Himabindu. Multi wall carbon nanoparticles induce oxidative stress and cytotoxicity in human embryonic kidney (HEK293) cells. Toxicology, 2010; 272: 11-16 (Impact factor=3.681)
    • 13. A. Rama Narsimha Reddy, P. Mahender Y. Narsimha Reddy and Devarakonda R. Krishna. Hypoglycemic and hypolipidemic activities of Trianthema portulacastrum plant in normal and alloxan induced diabetic rats, International Journal of Pharmacology. 2010; 6(2): 129-133 (Impact factor=1.503).
    • 14. A. Rama Narsimha Reddy, Y. Narsimha Reddy, Devarakonda R. Krishna and V. Himabindu. Translocation and extra pulmonary toxicities of multi wall carbon nanotubes in rats. Toxicology Mechanisms and Methods , 2010; 20(5): 267-272 (Impact factor=1.033)
    • 15. A. Rama Narsimha Reddy, Y. Narsimha Reddy, D. R. Krishna and V. Himabindu. Induction of oxidative stress and cytotoxicity by carbon nanomaterials is dependent on physical properties. Toxicology and Industrial Health. 2011;27:3-10 (Impact factor=1.423)
    • 16. Rama N. R. Anreddy, Rama K. Devarakonda, Himabindu Vurimindi and Narsimha R. Yellu. In Vitro Toxicity of Multi Wall Carbon Nanoparticles on Hep G 32 Liver Cell Lines. Latin American Journal of Pharmacy,2011; 30(1):177-80 (Impact factor=0.308)
    • 17. Bhukya Baburao, Anreddy Rama Narsimha Reddy, Bobbala Ravi Kumar, Yellu Narsimha Reddy and Gottumukkala Krishna Mohan. Analgesic and Anti-inflammatory Activities of the methanolic whole plant extract of Leucas Cephalotes (Roxb.ex Roth) Spreng. Braz J Pharm Sci. 2010; 46(3): 525-529 (Impact factor=0.276)
    • 18. Radhika T, Mahendar P, Venkatesham A, Rama Narsimha Reddy A, Narsimha Reddy Y, Sadanandam A and Christopher T. Hypoglycemic Activity of Red Kino Tree in Normal and Streptozotocin Induced Diabetic Rats. International Journal of Pharmacology. 2010; 6(3): 301-305 (Impact factor=1.503).
    • 19. S. Martha, K.R. Devarakonda, R.N.R. Anreddy and N. Pantam. Effect of aspirin treatment in Streptozotocin-induced type 2 Diabetic rats, Methods Find Exp Clin Pharmacol 2009; 31(5): 331-336 (Impact factor=1.14)
    • 20. Srinivas Martha, Rama N. R. Anreddy, Krishna R. Devarakonda and Narayana Pantam, Narsimha R. Yellu and Surender Thungathurthi. Role of Liver in Progression of Insulin Resistance in Relation to IGF-I and Insulin levels in Rats with Acute Hepatotoxicity, Latin American Journal of Pharmacy, 2009; 28 (6): 914-8 (Impact factor=0.308)
    • 21. Baburao Bhukya, Rama Narsimha Reddy Anreddy, Carey M. William and Krishna Mohan Gottumukkala. Analgesic and anti-inflammatory activities of leaf extract of Kydia calycina Roxb. Bangladesh J Pharmacology. 2009; 4: 101-104 (Impact factor=0.627)
    • Articles Published in International journals

    • 22. Gangarapu Kiran, Manda Sarangapani, Thumma Gouthami and Anreddy Rama Narsimha Reddy. Synthesis, characterization, and antimicrobial and antioxidant activities of novel bis-isatin carbohydrazone derivatives. Toxicological & Environmental Chemistry (online first)
    • 23. P. Maheshwari, B. Baburao, Ch. Pradeep Kumar and A. Rama Narsimha Reddy. Antidiabetic Activity of Methanolic Extract of Hiptage bengalensis Leaves in Alloxan Induced Diabetic Models. Pakistan Journal of Biological Sciences (Online first)
    • 24. A. Kishore Kumar, P. Kranthi Raju, Ch. Pradeep Kumar and A. Rama Narsimha Reddy. Plasma Lipid Profiles and Risk of Cardiovascular Disease on Occupational Exposure in Karimnagar. Toxicological and Environmental Chemistry. 2013; 95(2):359-366
    • 25. A. Rama Narsimha Reddy, J. Nagaraju, G. Rajyalakshmi, and M. Sarangapani. Cardio protective effect of N-(Benzo[d]oxazol-2-yl)-2-(5-Bromo-2-oxoindolin-3-y lidene) hydrazine carboxamide against doxorubicin induced cardiotoxicity in rats. Toxicological and Environmental Chemistry 2012; 94(10): 2012-2018
    • 26. G. Rajyalakshmi, A. Rama Narsimha Reddy, and M. Sarangapani. In vitro Antioxidant and Antibacterial activities of certain 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl)phenylimino} –indolin – 2 – one derivatives, Toxicological and Environmental Chemistry. 2012; 94(10): 2006-2011
    • 27. Shilpa Gantedi and Rama Narsimha Reddy Anreddy. Toxicological Studies of Zinc Oxide nanomaterials in rats. Toxicological and Environmental Chemistry, 2012; 94(9):1768-1779
    • 28. G. Sridhar Patwari, A. Rama Narsimha Reddy, A.V.N. Appa Rao and Y. Narsimha Reddy. Pharmacological screening of Dikamaliartane-A, A Cycloartane isolated from Gum Resin, Dikamali. International Journal of Applied Biology and Pharmaceutical Technology, 2011; 2(4):1-7
    • 29. Anreddy Rama Narsimha Reddy, Yellu Narsimha Reddy, Devarakonda Rama Krishna and Vurimindi Himabindu. In vitro cytotoxicity of multi wall carbon nanotubes on human cell lines. Toxicological and Environmental Chemistry, 2010;92(9):1697-1703
    • 30. A. Venkatesham, A. Rama Narsimha Reddy, P. Shankaraiah, Y. Narsimha Reddy, D. Rama Krishna and P. Narayana. Pharmacoepidemiology of diabetes mellitus in southern Indian patients. Int J Pharma Sciences. 2010;2(1): 400-403
    • 31. A. Shyam Sunder, A. Rama Narsimha Reddy, G. Kiran, and S. Thirumurugu. Anti-hyperlipidemic and Antioxidant Activity of methanolic extract of Trianthema portulacastrum plant in High fat diet fed Rats. Herbs, Spice and Medicinal Plants (In press)
    • 32. K. Prasanna Kumar, A. Rama Narsimha Reddy, Y. Narsimha Reddy and J. Anbu; Lipid lowering activity of lercanidipine in hyperlipidemic rats. Iranian J Pharmacology & Therapeutics. 2010; 9: 73-75
    • 33. Radhika T, Mahendar P, Venkatesham A, Ram Narsimha Reddy A, Narasimha Reddy Y, Rama Krishna D, Christopher T and Sadanandam A. Antioxidant and analgesic activities of Pterocarpus marsupium Roxb. Herbs, Spice and Medicinal Plants.2010; 16(1): 63-68
    • 34. A. Shyam Sunder, A. Rama Narsimha Reddy, D. Krishna Prasad, K. Poorna Chander and Sridhar Vemula. Free Radical Scavenging Activity of Methanolic whole plant extract of Trianthema portulacastrum Linn (Aizoaceae). Int J of Pharmaceutical Sciences, 2010;2(2):589-592
    • 35. A. Rama Narsimha Reddy, D. R. Krishna and Y. Narsimha Reddy. A Review on concepts of Nanotoxicology. Pharmacologyonline. 2008; 3: 175-186
    • 36. Venkata Rajesham V, Rama Narsimha Reddy A, Anbu J, and Narsimha Reddy Y. Pharmacokinetics of nifedipine in hyperlipidemic rats. Online Journal of PharmacoKinetics.2008; 4: 18-31
    • 37. K. Prasanna Kumar, A. Rama Narsimha Reddy, Y. Narsimha Reddy and J. Anbu; Effect of hyperlipidemia on the pharmacokinetics of lercanidipine in experimental rats. Pharmacologyonline. 2008; 3: 581-585
    • 38. Venkatesham Allenki, Rama Krishna Devarakonda, Rama Narsimha Reddy Anreddy, Narayana Pantam, Narsimha Reddy Yellu. Fasting and Post Prandial Monitoring of Dipeptidyl Peptidase-IV (DPP-IV)- A biomarker to assess Incretin response in type-2 diabetes. Stamford J Pharm Sci. 2009; 2(2): 81-85
    • 39. K. Prasanna Kumar, A. Rama Narsimha Reddy, Y. Narsimha Reddy and J. Anbu; Simultaneous determination of atorvastatin and lercanidipine in rat plasma by HPLC and pharmacokinetic studies, Asian J of Pharmacokinetics and Pharmacodynamics. 2008;8(4): 299-304
    • 40. N. Prasad, A. Rama Narsimha Reddy, A.Venkatesham, D.R Krishna and M.C. Prabhakara; Antioxidant activity of animal bile using frog heart as a model, Pharmacologyonline. 2008; 2: 390-396.
    • 41. N. Prasad, A.Venkatesham, A. Rama Narsimha Reddy and D.R Krishna and M.C. Prabhakara; Evaluation of antioxidant activity of different animals bile secretions, Int J Pharmacol. Biol Sci., 2008; 2(3):131-133.
    • 42. Sai Laxmi M., Venkatesham A, Rama Narsimha Reddy A. , Shankaraiah P, Rama Krishna D, Narsihma Reddy Y; Glibenclamide therapy in type 2 diabetes, Int J Pharm Sciences and Nanotechnology, 2009; 2 (1): 385-390.
    • 43. A. Shyam Sunder, A. Rama Narsimha. Reddy, Y. Rajeshwar, G. Kiran, D. K. Prasad, B. Baburao, S. Thirumurugu and A. Karthik, 2010. Protective effect of methanolic extract of Trianthema portulacastrum in atherosclerotic diet induced renal and hepatic changes in rats. Der Pharmacia Lettre. 2 (1): 540-545.
    • 44. G. Kiran, G. Rajyalakshmi, A. Rama Narsimha Reddy, J. Venkateshwar Rao and M. Sarangapani. Anticonvulsant Activity of Some Isatin-5-Sulphonamide Derivatives. Journal of Pharmacy Research, 2009; 2(3): 388-390
    • 45. Rajyalakshmi G, Shireesha B, Rama Narsimha Reddy A, Achaiah G and Raghu Ram Rao A. A modified asymmetric synthesis of (s)-atenolol: An enzymatic resolution. Journal of Pharmacy Research, 2009, 2(1), 1-4
    • 46. E. Venkateshwarlu, A. Rama Narsimha Reddy, A. Shyam Sunder and S. Madhusudhan. Anti-Hyperglycemic activity of methanolic extract of Salacia fruticosa leaves in alloxan induced Diabetic Rats. Drug Invention Today 2009, 1(2),95-97
    • 47. Vollala V. Rajesham, G. Rajyalakshmi, Anreddy Rama N. Reddy, K.Shekar and J. Anbu. Effect of Nifedipine on the Pharmacodynamic parameters of Simvastatin in hyperlipidemic rats. Journal of Pharmacy Research, 2009, 2(4), 642-643
    • 48. Prasanna Kumar Katnapally, Anbu Janaki, Rama Narsimha Reddy Anreddy, and Narsimha Reddy Yellu. Pharmacokinetics and Pharmacodynamics of atorvastatin alone and in combination with Lercanidipine in hyperlipidemic rats. Journal of Pharmacy Research, 2009; 2(1): 66-70
    • Articles Published in National journals

    • 49. Ch.Pradeep Kumar, chiranjeevi, B.Stephen Rathinaraj, D.Kumaraswamy, Bioequivalence And Pharmacokinetic Study Of Formulations Of Clobazam Tablets In Healthy Volunteers. International Journal of Preclinical and Pharmaceutical Research. 1(1); 2010: 44-49.
    • 50. Balasubramanyam, Pradeep Kumar Ch, Paramjit grover. In vivo Genotoxicity assessment of nano particles in comparision of Cyclophosphamide induced genotoxicity in Albino Rats using Comet assay, Toxicological letters. 54; 2009:134-141.
    • 51. B. Baburao, P. Raja Sridhar Rao, A. Rama Narsimha Reddy, K. Narasimha, B. Raja Narender, Y. Rajeshwar. In-vitro anti-oxidant activitiy of methanolic extract of baliospermum montanum. International J of Research in Ayurveda and Pharmacy. 2010;1(2): 611-615
    • 52. Baburao Bhukya, Rama Narsimha Reddy Anreddy and Krishna Mohan Gottumukkala. Analgesic and anti-inflammatory activities of leaf extract of Hiptage benghalensis (L.) Kurz. Biomedical and Pharmacology Journal, 2009; 2(1): 161-164
    • 53. Kranthi Gadidasu, A. Rama Narsimha Reddy, Pavan Umate, Y. Narsimha Reddy, Sadanandam Abbagani. Antioxidant and anti-diabetic activities from leaf extracts of Streblus asper Lour. Biotechnology; an Indian Journal. 2009; 3(4): 231-235
    • 54. Gudipati Rajyalakshmi, Anreddy Rama Narsimha Reddy and Vollala Venkata Rajesham. A comparative antihyperlipidemic activity of atorvastatin with simvastatin in rats. The Internet Journal of Pharmacology, 2009, 6(2), 1-6
    • 55. N. Prasad, A. Rama Narsimha Reddy, A.Venkatesham, S. Pranavi, Y. Venkaiah, D.R.Krishna and M.C. Prabhakara, Effect of animal bile on the actions of acetylcholine using isolated frogs rectus abdominus muscle, Indian Journal of Comparative Animal Physiology, 2008; 26(1): 23-30.