Research Pharmaceutics
Title of Research program Implemented / being Implemented.

    *  Design and Development of herbal formulations for Anti Diabetic Activity.
    *  Isolation of pure natural polymers for pharmaceutical formulations.
    *  P.K & P D studies of Herb – Drug interations.
    *  Design & Development of multi layered tablets for controlled release formulations.
    *  Noval drug Delivery Systems.
    *  Preparation & Evaluation of transdermal patches.
    *  Microspheres.
    *  Preparation & Evaluation of neosomes.
List of Publications
1. Bookya Padmaja, Raparla Ramakrishna and Sriramula Sravani., Formulation and Evaluation of Fast Dissolving Tablets of Captopril. Journal of Pharmacy Research 2014, 8(7),963-968. Impact Factor TM ( India ) 2.667.
2. Prasenjit Mondal, Satla Shobha Rani and Raparla Ramakrishna. Novel Stability Indicating Validated RP-HPLC Method for Simultaneous Quantification of Artemether and Lumefantrine in Bulk and Tablet. Current Pharmaceutical Analysis; 2014; 10(4):271-278. Impact Factor: 0.771
3. Shravan Kumar Dholi1, Ramakrishna Raparla and Kannappan. In vivo anti diabetic evaluation of gymnemic acid in streptozotocin induced rats., The Pharma Innovation Journal 2014; 3(7): 82-86
4. Shravan Kumar Dholi1, Ramakrishna Raparla and Kannappan. Effect of Gymnema sylvestre on the Pharmacokinetic and Pharmacodynamic of Oral Hypoglycemic Drug - Gliclazide in Streptozotocin Induced Diabetic Rats., Annual Research & Review in Biology, 4(22): 3373-3385, 2014.
5. Shravan Kumar Dholi, Ramakrishna Raparla and Kannappan. Effect Of Gymnema Sylvestre On The Pharmacokinetics And Pharmacodynamics Of Oral Hypoglycemic Drug – Glibenclamide In Stz Induced Diabetic Rats., WJPR, Vol 3, Issue 4, 2014. (SJIF Impact Factor 5.045)
6. Y. Ankamma Chowdary, Ramakrishna Raparla, and Muramshetty Madhuri. Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin hydrochloride., Journal of Pharmaceutics Volume 2014, Article ID 848243, 14 pages. http://dx.doi.org/10.1155/2014/848243.
7. Prasenjit Mondal, S Shobharani and R.Ramakrishna. A New Stability Indicating Quantitative Rp-Hplc Method For Blonanserin-A Novel Antipsychotic Agent., Indo American Journal Of Pharm Research., 2014; 4(04); 1968-1975.
8. Shravan Kumar Dholi , Ramakrishna Raparla and Kannappan. In-Vivo Antidiabetic Evaluation of Capsicum Extract in Alloxan Induced Rats., Int.J.Nov.Res.Eng & Pharm.Sci., Vol 1, Issue 01; 48-53.
9. Krishna R. Raparla, YA Chowdary, Sushma P. Formulation and Evaluation of Bilayered Tablets of Anti-Platelet Drugs., Am. J. PharmTech Res. 2014; 4(1); 855-868. Impact Factor – 0.968
10. Shravan Kumar Dholi, Ramakrishna Raparla, Kannappan. In Vivo Antidiabetic Evaluation of Gymnema sylvestre Extract in Streptozotocin Induced Diabetic Rats., Int. J. Pharm. Sci. Rev. Res., 23(2), Nov – Dec 2013; 25, 142-146. Impact Factor – 1.704
11. Ramakrrishna Rapaarla, Ankaamma Chowwdary Y, Srrikanth Thaatipamula and S.Pragnna. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Candesartan., AJADD; 1[4]; 2013; 369-386.
12. Prasenjit Mondal, Santhosh. B, Sobha Rani Satla and Ramakrishna Raparla. A new validated simultaneous RP-HPLC method for estimation of Escitalopram Oxalate and Etizolam in bulk and tablet dosae form., Der Pharma Chemica., 5(3); 2013; 26 – 32.
13. Shravan Kumar Dholi, Ramakrishna Raparla, Kannappan. Effect of Gymnema Sylvestre on the Pharmacokinetics and Pharmacodynamicsof Gliclazide in Diabetic Rats., AJPCT., 1(1); 2013; 023-036.
14. P.Nagadivya, R. Ramakrishna, G. Sridhar and R. Bhanushashank. Effect of Various Binding Agents on Tablet Hardness and Release Rate Profiles of Diclofenac Sodium Tablets., Int. J. Res. Pharm.Sci., 2012; 3(1): 12-16.
15. P Mondal, S Jana, A Balaji, R Ramakrishna, LK Kanthal. Synthesis of some new isoxazoline derivatives of chalconised indoline 2-one as a potential analgesic, antibacterial and anthelmimtic agents., J. Young Pharmacist.2012; 4(1): 38-41. Impact Factor – 0.348
16. Ramakrishna Raparla1, and Eswara Gopala Krishna Murthy Talasila. Design and evaluation of floating drug delivery systems of Metformin with natural gums as release retarding polymers., Int. J Adv in Pharmaceutics 1 (1) 2012
17. Shravan Kumar Dholi, Ramakrishna Raparla, and Kannappan. In Vivo Antidiabetic Evaluation of Aloe Vera In Alloxan Induced Rats., INT.J.PH.SCI.,Sep-Dec,2011;3(3): 1482-1486.
18. Shravan Kumar Dholi, Ramakrishna Raparla, Kannappan. Synergic Activity of Fenugreek seeds and Neem leaf extracts against Alloxan induced diabetic rats., Int. J. PharmTech Res. 2011;3(4): 1963-1970.
19. Nishanth Kumar N, Ramakrishna Raparla, Santhosh Kumar M. Development and Evaluation of Mucoadhesive Microspheres of an Anti-Diabetic Drug with Natural Polymer. Int J Pharm Res, 2011; 3(4): 48-53.
20. Santhosh Kumar Mankala, Nishanth Kumar Nagamalli, Ramakrishna Raprla, Rajyalaxmi Kommula., Preparation and Characterization of Mucoadhesive Microcapsules of Gliclazide with Natural Gums., S. J. Pharm. Sci. 2011; 4(1): 38-48.
21. Rama K. RAPARLA, Eswara G.K.M. TALASILA, Santhosh K. MANKALA & Candasamy MAYUREN., Mucoadhesive Microcapsules of Glipizide Formulated with Gum Kondagogu: In Vitro and In Vivo Evaluation., Lat. Am. J. Pharm. 2011; 30 (7): 1253-9. Impact Factor .308
22. Shravan Kumar Dholi, Ramakrishna Raparla, Santhosh Kumar Mankala, Kannappan Nagappan., In Vivo Antidiabetic Evaluation of Fenugreek Seeds Extract in Alloxan Induced Rats., Int J Cur Sci Res. 2011; 1(3): 96 – 104.
23. Shravan Kumar Dholi, Ramakrishna Raparla, Santhosh Kumar Mankala, Kannappan Nagappan., Invivo Antidiabetic evaluation of Neem leaf extract in alloxan induced rats., Journal of Applied Pharmaceutical Science 01 (04); 2011: 100-105.
24. Nishanth Kumar N*, Ramakrishna Raparla, Santhosh kumar M., Formulation And Evaluation Of Gliclazide Mucoadhesive Microspheres with Natural Polymer., Int.J.Ph.Sci., 2011;3(1)., 1050-1059.
25. Ramya Kalakuntla, Upendar Veerlapati, Madhavi Chepuri, Ramakrishna Raparla. Effect of Various Super Disintegrants on Hardness, Disintegration and Dissolution of Drug from Dosage Form. J Adv Sc Res, 2010; 1(1): 15-19.
26. Mankala Santhosh Kumar, Ramakrishna Raparla, Nagamalli Nishanth Kumar. Development and evaluation of oral controlled release formulations of gliclazide using natural polymers. Int Res J Pharm, 2010; 1(1): 233-242.
27. Santhosh Kumar M, Ajaykumar Patil, Ramakrishna R, Dana SB, Vijay Kumar N. Formulation and evaluation of intragastric hydrodynamic balanced system of itopride hydrochloride. Res J Pharm Bio Chem Sci, 2010; 1 (2): 137-142.
28. Raparla Rama Krishna, Talasila Eswara Gopala Krishna Murthy. Preparation and evaluation of mucoadhesive microcapsules of glipizide formulated with gum kondagogu: In vitro and in vivo”. Acta Pharmaceutica Sciencia, 2010; 52: 335-344.
29. Ashwin Kumar T S, Kameswara Rao CH, Gurudeep N, Rama Krishna Raparla. Design and Evaluation of Binding, Compression, Release Properties of PVP-K30 in the Formulation of Paracetamol Tablets. Inventi Rapid: Pharm Tech, 2010; 1(3): 1-5.
30. Katteboina Suman, Rama Krishna Raparla, Talasila Eswara Gopala Krishna Murthy. Formulation and Optimization of Directly Compressible Ambroxol HCl Controlled Release Matrix Tablets. Research J Pharm Tech. 2010; 3(1): 263-266.
31. Raparla Ramakrishna, Nagabandi Vijaykumar and Katteboina Suman. Development and evaluation of ambroxol hydrochloride sustained release tablets using HPMC as polymer. J Global Pharm Tech, 2009; 1(1): 88-93.
32. Rama Krishna R, Gopala Krishna Murthy T E and Hima Bindu V. Design and development of mucoadhesive microcapsules of Glipizide formulated with gum karaya. J Pharmacy Res, 2009; 2(2): 208-214. Impact Factor 2.507 (India)
33. Rama Krishna R, Ankamma Chowdary Y, Hima Bindhu V and Gopala Krishna Murthy TE. Formulation and evaluation of mucoadhesive microcapsules of Glipizide: Influence of process variables. Int J Pharmacol Biol Sci, 2008; 2(3): 73-79.
34. Rama Krishna R, Ankamma Chowdary Y, Hima Bindhu V and Gopala Krishna Murthy TE. Formulation and evaluation of mucoadhesive microcapsules of Glipizide with gum karaya: Influence of process variables. Pharma Bio World, 2008; 47-51.
35. Rao TV, Rama Krishna R, Murthy TEGK and Vidyadhara S. Formulation and evaluation of Cefadroxil dispersible tablets: Direct compression technique. The Pharma Review, 2008; 6(33): 135-137.
36. Ravi Kumar A, Harish R and Rama Krishna R. Phytochemical and Antibacterial Properties of Calotropis gigantean R.Br. Int J Pharm Biol Sci.2007; Vol.1 (1): 75-77.
37. Rama Krishna R and Murthy TEGK. Formulation and evaluation of oral controlled release Glimepiride matrix tablets, Adv Pharmacol Toxicol, 2007; 8(2): 59-62.
38. Karshak Kosaraju, Rama Krishna R, Lakshmi Suvarchala R and Gopala Krishna Murthy TE. Design and development of alginate beads containing mucoadhesive polymers for oral controlled release of Glimepiride. Technology Spectrum, 2007; I (3): 22-28.
39. Divya SA, Krishna AV, Krishnanjaneyulu I, Ramakrishna R, Chowdary YA and Murthy TEGK. Commercial evaluation of Diclofenac Sodium ampoules. The Indian Pharmacist, 2006; V (45): 71-72.
40. Suvarna Lakshmi J, Rama Krishna R, Chowdary YA and Murthy TEGK. In Vitro Evaluation of Commercially available Naproxen Tablets. The Antiseptic, 2004; Vol. 101(10): 455-456.
41. Subba Rao K, Ramesh SV, Srinivasa Rao UV, Kishore VVP, Rama Krishna R and Abbulu K. Effect of Formulation Adjuvants and site of Surfactant on the Release of Nimesulide from Tablets. The Indian Pharmacist, May 2003; 53-56.
42. Rama Krishna R, Susmita Sing and Ravi TK. Effect of Anti-Coagulants on the T-Cell Receptors. Online Publication, 2003.