M.Pharmacy-Pharmaceutics
COURSE STRUCTURE AND SYLLABUS
I YEAR I SEMESTER
Group Subject L P Credits
Modern Pharmaceutical Analytical Techniques 3 0 3
Advanced biostatistics and research methods 3 0 3
Biopharmaceutics and Pharmacokinetics 3 0 3
Advanced Physical Pharmaceutics 3 0 3
Advanced pharmaceutical technology-I 3 0 3
Lab Modern Pharmaceutical Analytical Techniques Lab 0 3 2
Lab Advanced Physical pharmaceutics Lab 0 3 2
Seminar - - 2
Total Credits 21

MODERN PHARMACEUTICAL ANALYTICAL TECHNIQUES
(Common to all Branches)

Unit-I:

A detailed study of separations and determination involved in the following chromatographic techniques.

     a. Column chromatography : Theory, preparation, procedures, methods of detection.
    b. This layer chromatography : Theory, preparation, procedures, detection of compounds
    c. Paper Chromatography : Theory, different techniques employed, filter papers used, quantitative and quantitative detections.
    d. Counter current extraction, soild phase extraction techniques.

Unit-II
    a. Gas chromatography: fundamentals, Instrumentation, columns preparation and operations, detection, derivitasation, LC-MS, GC-MS.
    b. HPLC : Principles and Instrumentations.

Unit-III
    a. UV-Visible Spectroscopy : Principle, Beer Lambert’s law, study and working principle of instrumentation, applications in pharmaceutical analysis and derivatives spectroscopy.
    b. IR Spectroscopy: Theory, different types of molecular vibrations, sampling techniques, instrumentation and applications in pharmaceutical analysis, FTIR
    c. Flurorimetry: Theory, fluorescence and chemical structure, factors affecting the fluorescence, study of working principles of the instrument and applications in pharmaceutical analysis.

Unit-IV
    a. NMR: theory, Chemical-shift, spin-spin coupling, shielding, working principle of instrumentations and applications in pharmaceutical analysis, HNMR, and cosy 13CNMR.
    b. Mass: principle, different methods of production of ions metastable ions, working principle of mass spectrometer and applications in pharmaceutical analysis.

Unit-V
    a. Differential thermal analysis, partial thermal analysis.
    b. Radiometric techniques, Radio immunoassay, Elisha test.
    c. X-ray diffraction, polarimetry.

ADVANCED BIOSTATISTICS AND RESEARCH METHODS

Unit-I :
Developing a research question, Resources for research question, Literature Review: Traditional Qualitative Review Meta Analysis A Quantitative Review Preparation of Research Proposal

Variables—Definition of Variable, Types of variables—Dependent and Independent variables, Confounded variables, Measurement of variables, Types of measurement scales and their comparison. Reliability and Validity of Measurements.

Unit-II :
Validity, Types of validity—Internal validity, Construct validity, External validity, Threats to validity.
Control: Subject as own control (Within Subject control), Statistical control.

Unit-III:
    Non-experimental Research:
    Part 1—Observational, Archival and Case-Study Research: The Hermeneutic Approach.
    Observational Research: Naturalistic Observation, Participant-Observer Research.
    Archival Research: Archival Data Collection and Compilation. Case Studies: Characteristic of Case Studies.
    Non-experimental Research: Survey Research—Designing of Questionnaire, Methods of Administration, Response Rates. Types of Samples—Haphazard            Samples,     Purposive Samples, Convenience Samples and Probability Samples.

Unit-IV :
    True Experiments: Single-Factor Designs, Factors, Levels, Conditions, and Treatments. Within-Subject Designs.
    True Experiments Part-2—Factorial Designs—Main Effects, Interactions, A Mixed Factorial Design.

Unit V :
    Single-Subject Experiments: Advantages and Disadvantages. Quasi Experiments: The differences between Quasi and True Experiments.
    Design without Control Groups—Interrupted Time Series Designs and Repeated Treatment Designs.

Text Books
        1. Donald H. McBurney -Theresa L. White “Research Methods” ( Cengage learning India Pvt. Ltd)
        2. Statistics for business and economics 3rd edition by-Hooda-R.P- MC. Millan Business books
        3. Biostatistics & Computer applications by GN Rao and NK Tiwari

Reference Books
    1. Remingtons pharmaceutical Sciences
    2.. Theory & Practice of Industrial Pharmacy by Lachman

TADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY – I

Unit-I
. Stereochemistry: a. Elements of symmetry, simple axis of symmetry . Notation, relative configuration and absolute configuration .Compounds with a chiral carbon atom, compounds with other quadrivalent chiral atoms. Optical isomerism in compounds containing no chiral atom, biphenyl, allenes, compounds with exocylic double bonds and spirans.
    b Chirality due to helical shape.. Cis / Trans, E – Z isomerism resulting from double bonds, monocyclic compounds, fused ring system. Racemic modifications and methods for resolution of racemic mixtures. Asymmetric synthesis and stereo – selective synthesis.

Unit-II
.     a. Reactive Intermediates: Definitions, generation, stability, structure and reactivity of free radicals carbocations, carbanions, carbenes, Nitrenes/Nitrenium ions.
      b. . Concepts of aromaticity and anti aromaticity, non benzenoid aromatic compounds.

Unit-III
Mechanisms of organic reactions: Free radical, Electrophilic, Nucleophilic reactions of aliphatic and aromatic compounds

Unit-IV Elimination Reactions: E1, E2, E1CB and E2CB mechanisms, Mechanisms and orientation in Pyrolytic eliminations, effect of substrate structure, Attacking base, leaving group and reaction bond, medium and reactivity addition to carbon – carbon multiple bond reactions. Mechanisms, Orientation and reactivity.

Unit-V
. Electrocyclic, pericyclic and sigmotropic reactions: introduction, terminology and mechanism with suitable examples.

Recommended Books
    1. Francis A. Carey & Richard J. Sunberg, Advanced Org. Chemistry , III rd Edition , Par B; Reactions and synthesis , Plenum Press, new York , London , Latest Edition.
    2. Eliel I. Ernest and Samuel h, Stereochemistry of Org. Compounds, John Wiley and sons, New York, 2003 Edition.
    3. Roland E. Lehr & Alan P Marchard, Orbital Symmetry: A Problem solving approach, Academic Press, New York Latest Edition.
    4. J. March , Advanced Org. Chemistry , Reactions Mechanisms and Structure , 4th Edition, John Wiley & Sons , New York Latest Edition
    5. I. L. Finar , Organic Chemistry , ELBS
    6. Herbert O. Modern Synthesis Reactions IInd Edition W.A. Beenamis Inc. Menco Park California
    7. W. Carruthers, Some Modern Methods of Org. Synthesis, III rd Edition, Cambridge University Press, Cambridge.